Nioh 2 can be a confusing game to those that first start it, especially if they haven't played the first game yet. One massive thing the game does not tell you is how to exit any mission in the game.
So how do you quit a mission? You can exit any mission by going into the equipment menu and using the Divine Branch Fragment. This item has unlimited uses, but you will lose all of your Amrita if you choose to use it.
You can put it into your shortcuts, but that is risky in that you might accidentally hit it and leave the mission when you don't want to.
How do missions work in Nioh 2?
Nioh 2 missions are divided into main missions, optional side quests, and Twilight Missions. It has multiple paths to take during the game which is why it's important to choose your mission wisely.
It has a more open world feel to it, but you are still confined in some ways. You cannot go to Nioh 2 side quests until you beat the main story mission they are attached to unless it is in a different location than the main missions.
Twilight Missions are Nioh 2 side quests that can be accessed after you beat Nioh 2 main missions, and are some of the hardest missions in the game.
Can I quit a mission without losing Amrita?
Amrita is the life-blood of your character because it is used to upgrade basic character stats. Without it, you can't upgrade your health, stamina, damage, and all the other good stats.
There is only one way to not lose your Amrita when leaving a mission and that is by using a Himorogi Branch. It is basically the same as a Divine Branch Fragment and lets you keep all Amrita, but there are only a number of uses to it.
The branch is very rare, so only use it if you absolutely have to. Don't be afraid to lose Amrita though because you can always get more in the future. Most of the time, you can just go to your shrine and use all the Amrita, and then use the fragment to leave.
Does the mission reset when you leave?
Yes, the mission resets entirely when you exit using the branch fragment. Thankfully, the missions aren't too long so you won't have to spend 30 hours redoing each mission if you do end up leaving.
Side missions will typically reset only the current section you are in unless it's the main missions. It features a lot of unique, open-world areas so if you leave, the enemies and your position go back to where they were before.
There is no penalty to quitting missions other than losing Amrita. However, it isn't exactly the easiest game so you still want to think about quitting before doing so. Take your time and always look at the mission requirements to make sure you are ready for it.
Just make sure you have a reason to leave. If you don't, then stay and finish the mission, unless you are stuck and not ready for the upcoming fights.